Facts, benefits of trans Resveratrol, ResveraGEN
TABLE OF CONTENTS
What is Resveratrol?
Natural, Extract or Made: Best?
Resveratrol Benefits
3 WAYS TO SPOT A FAKE
WHY IS GMP CERTIFICATION CRITICAL?
Resveratrol Supplements – Product Reviews
COMPANY BACKGROUND
The UltraHealth Store stands as a pioneer in the realm of biochemical science, specializing in the production of pharmaceutical-grade anti-aging compounds with a purity of 99+% . Our affiliation with the FDA-approved cGMP and our parent company, GSK International, has empowered us to serve the scientific, research, and consumer sectors with our high-grade products since 2015.
The supplement industry, despite being crowded, often lacks comprehensive regulation, leading to a sea of information that can be biased or promotional. Unlike many others, UltraHealth derives its knowledge from meticulous clinical studies from respected sources such as the National Institute of Health, the Journal of Biological Chemistry, and ongoing research from leading U.S. health institutions.
What is Resveratrol?
Resveratrol is a natural polyphenolic compound that can be found in certain plants and foods. It has gained significant attention in recent years due to its potential health benefits. Here's an overview of its history:
Discovery:
- Resveratrol was first isolated and identified in 1940 by a Japanese scientist named Michio Takaoka. He extracted it from the roots of a plant called white hellebore (Veratrum grandiflorum), which is native to Japan.
Early Research:
- Initial research on resveratrol was limited, and its potential health benefits were not widely explored in the early years after its discovery.
Red Wine Connection:
- Resveratrol gained widespread attention in the 1990s when scientists proposed a potential link between the consumption of red wine and the "French Paradox." The French Paradox referred to the observation that despite a diet relatively high in saturated fats, the French had lower rates of heart disease compared to some other countries. Resveratrol was suggested as one of the compounds in red wine that might be responsible for this phenomenon.
- Due to the interest in its potential health benefits, resveratrol supplements became widely available in the early 2000s. These supplements were marketed as a way to potentially improve heart health, combat aging, and offer other health advantages.
Continued Research:
- Over the years, research on resveratrol has continued, and numerous studies have explored its effects on various health conditions, including heart disease, cancer, diabetes, and neurodegenerative diseases. While some studies have shown promising results, others have yielded inconclusive or conflicting findings.
Current Status:
- As of my last knowledge update in January 2022, resveratrol remains a topic of ongoing scientific research. While it has shown potential health benefits in animal and cell studies, its precise effects in humans and the optimal dosage for specific health conditions are still areas of active investigation.
It's important to note that while resveratrol is naturally found in some foods, particularly red grapes and red wine, the levels are relatively low. As a result, some people choose to take resveratrol supplements to potentially increase their intake. As with any dietary supplement, it's essential to consult with a healthcare professional before adding resveratrol supplements to your regimen, as individual responses and potential interactions with medications can vary.
Back to Table of Contents
Natural, Extract or Made: Best?
Resveratrol is naturally found in various plant sources. Here are some common natural sources of resveratrol:
-
Red Grapes: Resveratrol is most commonly associated with red grapes and red grape products, including red wine. The skin of red grapes contains a higher concentration of resveratrol compared to the flesh.
-
Red Wine: Red wine is often touted as a source of resveratrol due to the presence of this compound in grape skins. However, the amount of resveratrol in red wine can vary widely depending on the grape variety, winemaking process, and aging.
-
Purple and Red Berries: Certain berries, such as blueberries, cranberries, and bilberries, contain resveratrol. The skin of these berries is a particularly good source.
-
Peanuts: Resveratrol can also be found in peanuts, particularly in the skins. Peanut butter made from whole peanuts may contain some resveratrol.
-
Japanese Knotweed: This is a plant native to Asia, and it is considered one of the richest sources of resveratrol. However, it's not commonly consumed as a food.
-
Cocoa and Dark Chocolate: Cocoa powder and dark chocolate have been found to contain small amounts of resveratrol, primarily due to the cocoa bean's skin.
-
Red and Purple Onions: Some varieties of red and purple onions contain resveratrol, although the levels can vary.
-
Pistachios: Pistachio nuts may contain modest amounts of resveratrol.
-
Giant Knotweed: Similar to Japanese Knotweed, this plant is another source of resveratrol.
-
Mulberries: These dark-colored berries can also contain resveratrol.
It's important to note that the resveratrol content in these natural sources can vary widely, and consuming them alone may not provide a significant amount of the compound. For example, while red wine contains resveratrol, excessive alcohol consumption is not recommended for health reasons.
Extracted & Ground Root Powder Issues
Most supplement for resveratrol use Japanese Knotweed (grown in mostly in China, not Japan).
Japanese Knotweed (Reynoutria japonica) is a highly invasive plant species, and its roots can contain compounds that some researchers have referred to as "toxins" due to their allelopathic effects on other plants and their ability to contribute to the plant's invasive nature. Here are some key compounds and aspects related to the "toxins" found in the roots of Japanese Knotweed:
-
Tannins: Japanese Knotweed roots contain high levels of tannins, which are polyphenolic compounds. These tannins are thought to have allelopathic properties, meaning they can inhibit the growth of other plants in the vicinity. This can help the knotweed outcompete native plant species and contribute to its invasive nature
-
Oxalates: Some studies have reported the presence of oxalates in Japanese Knotweed, particularly in the leaves. Oxalates can be problematic for some individuals when consumed in large quantities as they can contribute to kidney stone formation. However, the roots are not typically consumed, so this is less of a concern.
-
Rhizomes: Japanese Knotweed spreads primarily through its underground rhizomes, which are the underground stems or roots. These rhizomes can grow rapidly and densely, making it difficult to control and eradicate the plant once it has established itself.
Here are some common soil toxins or contaminants that can be found in Chinese farmland:
-
Heavy Metals: Heavy metals such as cadmium, lead, arsenic, and mercury can accumulate in soil due to various sources, including industrial pollution, the use of contaminated water for irrigation, and the application of certain fertilizers and pesticides. These metals can be toxic to plants and, when absorbed by crops, can pose health risks to humans who consume contaminated produce.
-
Pesticides and Herbicides: The use of pesticides and herbicides in agriculture can leave residues in the soil. Some of these chemicals can persist in the environment for extended periods, potentially leading to soil contamination.
-
Industrial Pollution: Farms located in or near industrial areas may be at a higher risk of soil contamination from pollutants released by nearby industries. These pollutants can include chemicals, heavy metals, and even hazardous waste.
-
Persistent Organic Pollutants (POPs): Certain organic pollutants, such as polychlorinated biphenyls (PCBs) and dioxins, can persist in the soil and may accumulate over time. These substances can have detrimental effects on soil quality and may bioaccumulate in crops.
-
Excessive Fertilizer Use: Overuse of chemical fertilizers can lead to imbalances in soil nutrient levels and pH, potentially affecting soil health and crop growth.
-
Water Pollution: The quality of irrigation water used on farms can impact soil quality. Contaminated water sources can introduce pollutants into the soil.
-
Soil Erosion: Soil erosion, often exacerbated by unsustainable farming practices such as over-tilling and deforestation, can lead to the loss of topsoil and the exposure of subsoil, which may have different chemical properties and contaminants.
Resveratrol Benefits
Resveratrol, a natural compound found in certain plants, particularly in the skin of red grapes, peanuts, and some berries, has been the subject of numerous studies exploring its potential health benefits. While research on resveratrol is ongoing, here are some of the potential benefits of resveratrol in detail:
-
Antioxidant Properties: Resveratrol is a potent antioxidant, which means it helps neutralize harmful free radicals in the body. By reducing oxidative stress, it may protect cells and DNA from damage, potentially slowing down the aging process and reducing the risk of chronic diseases.
-
Cardiovascular Health: Resveratrol has been associated with several cardiovascular benefits, including:
- Reduced LDL Cholesterol: It may help lower levels of LDL (bad) cholesterol, reducing the risk of heart disease.
- Improved Blood Flow: Resveratrol may promote better blood vessel function, which can lead to improved circulation and reduced blood pressure.
- Anti-Inflammatory Effects: It has anti-inflammatory properties that may contribute to heart health by reducing inflammation in blood vessels.
-
Cancer Prevention: Some studies suggest that resveratrol may have anticancer properties. It may inhibit the growth of cancer cells and prevent them from spreading. Research in this area is ongoing, and more studies are needed to fully understand its potential role in cancer prevention and treatment.
-
Blood Sugar Regulation: Resveratrol may help improve insulin sensitivity and regulate blood sugar levels, which can be beneficial for individuals with diabetes or those at risk of developing the condition.
-
Neuroprotective Effects: Resveratrol has shown promise in protecting brain cells from damage and reducing the risk of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. It may also enhance cognitive function and memory.
-
Longevity: Some animal studies have suggested that resveratrol may extend lifespan and promote healthy aging by activating certain genes associated with longevity. However, these findings require further research and validation in humans.
-
Anti-Inflammatory Properties: Resveratrol has anti-inflammatory effects that may be beneficial for individuals with chronic inflammatory conditions, such as arthritis or inflammatory bowel disease.
-
Skin Health: Resveratrol's antioxidant properties may help protect the skin from UV damage and oxidative stress, potentially reducing the signs of aging and improving overall skin health.
-
Weight Management: Some studies have suggested that resveratrol may aid in weight management by increasing metabolism and reducing fat accumulation.
3 WAYS TO SPOT A FAKE
Unfortunately, the most foolproof method to confirm the authenticity of your dietary supplement is through independent testing, which can be costly.
Major online platforms like Amazon, Walmart, and iHerb aren't always reliable in weeding out subpar products. Today, many supplement brands resort to using fabricated test results, reviews, and GMP certifications to promote their potentially dubious items. Furthermore, the myriad of supplement review websites that populate Google Search often lack comprehensive product analyses. Despite their proclamations of championing consumer health, several of these sites are motivated by referral earnings, which could jeopardize the integrity and safety of the supplements they vouch for.
However, there are other ways to independently evaluate the trustworthiness of dietary supplement brands without incurring costs.
We'll delve into how the following free tools can offer insights, starting with a mere glance at a product's label.
- UPC lookup link - GS1
- FDA supplement label regulations link - FDA Label
- GMP Company lookup link - FDA Database
1. UPC code lookup - If your supplement bottle has a UPC code just go to GS1 and navigate down, choose GTIN (the formal term for a UPC code). Enter the complete number into the search bar. After clicking search, the government database will swiftly provide the company's details. If you get a response saying the UPC code is invalid, it implies it's not a genuine UPC code. Steer clear of such products!
If you're unable to locate a UPC code or if the company doesn't display it on their website, you can search using the company's name.
Moreover, if the company name appears but doesn't align with the one you're investigating, it's possible that it was unlawfully duplicated and affixed to the bottle.
2. FDA supplement label regulations - Examine the right portion of your supplement bottle where the 'Supplement Facts' are displayed. This label should detail the specific name of the active ingredient, its dosage, quantity, and the full address of the company either selling the product or listed under 'manufactured for'. To view the comprehensive guidelines for dietary supplement labeling, simply click. FDA Label.
If the company's label isn't in line with FDA standards, it suggests they aren't utilizing a certified GMP. A genuine GMP would prevent a bottle from being inaccurately labeled or lacking essential information.
The above illustration accurately presents resveratrol. Resveratrol is available in two forms: standard and trans. A certified GMP, upon receiving the bulk compound, would expect the correct COA (certificate of analysis) specifying the type of resveratrol supplied. If only "resveratrol" is mentioned without specifics, it would be marked as incorrect if trans resveratrol was supplied, and the GMP would halt the manufacturing process.
3. GMP Company Search Link - It's rare for companies to display their GMP certificate, which carries the name of the FDA-approved GMP entity. If you possess the name of the GMP, you can simply enter it into the search bar on this website: FDA Database. This will display the company's inception date, the number of inspections they've undergone, and any violations they might have.
Should your supplement company not disclose this information, consider reaching out to them via phone or email to inquire. If they decline to share or claim it's confidential, proceed with caution. A reputable company would willingly and confidently share such details with their clientele.
WHY IS GMP CERTIFICATION CRITICAL?
GMP, an acronym for "Good Manufacturing Practice," is a protocol designed to guarantee that products are routinely produced adhering to quality benchmarks. A "certified GMP" facility has been evaluated and fulfills the GMP standards set by the respective regulatory agencies. In the U.S., the FDA manages GMP guidelines for food, pharmaceuticals, and medical devices. When a business mentions its products are sourced from a "GMP certified" or "GMP compliant" establishment, it indicates that the production methods have been assessed and conform to the rigorous criteria determined by the appropriate regulatory authority.
why does GMP certification matter?
-
GMP (Good Manufacturing Practice): Designed to guarantee products are consistently produced according to quality standards.
-
Certified GMP Facility:
- An establishment that's been inspected and meets GMP criteria.
- Adheres to standards set by regulatory agencies.
-
FDA Oversight:
- Governs GMP guidelines in the U.S.
- Applicable to sectors such as food, pharmaceuticals, and medical devices.
-
GMP Certification in Companies:
- When a product is labeled as "GMP certified" or "GMP compliant", it means:
- Production methods have been scrutinized.
- Processes align with stringent standards of the relevant regulatory body.
- When a product is labeled as "GMP certified" or "GMP compliant", it means:
how to ask a supplement company for their GMP? Just contact them.
Dear company XYZ,
I'm interested in purchasing (or continuing to purchase) your product. Could you please provide me with the name of your GMP so I can reach out to them directly?
Based on just a bit of FDA label information, it's apparent that many of the unsuccessful companies weren't genuine. We examined the labels of all these companies, and none passed the basic FDA standards tests highlighted earlier.
Resveratrol Supplements – Product Reviews
Below, we've ranked companies based on their current resveratrol products. Our evaluation is rooted in cross-referencing information from official government sites and ensuring the details on the bottles adhere to regulatory and legal standards. Additionally, we assess bioavailability, considering factors like the presence of liposomal capsules and the purity of active ingredients. If products are on par in these aspects, we then categorize them based on the price per gram of trans resveratrol.
It's worth noting that while some companies advertise their products as liposomal, they aren't genuinely so. For a deeper understanding, refer to our blog titled 'The Lipo Lie'.LINK. It is a must read.
The ranking system goes up to 6 stars, with companies scoring 3 stars and above considered dependable. Companies with ratings below 3 stars are ones we believe you should approach with caution or avoid entirely.
NOTE: Extracted and rood powder are not considered 100% safe. Pure synthesized trans resveratrol does not have any toxins or heavy metals since it is pure and made in the lab.
Here is how to calculate cost per gram of the active ingredient:
- serving per bottle x mg per serving - X (mg per bottle)
divide X by 1000 = Y (grams per bottle)
divide the price of one bottle by Y = $/gram
UltraHealth - Score 6 out of 6
The only company posting their real GMP certificate, real Liposomal capsules, & only one inert additive.
GENEX - Score 3 out of 6
DOUBLEWOOD - Score 3 out of 6
LIFE EXTENSION - Score 3 out of 6
PROHEALTH - Score 3 out of 6
The above companies are considered reliable.
TONIIQ - Score 3? out of 6
NOOTROPICS - Score 3? out of 6
LUMINA - Score 2 out of 6
RENUE BY SCIENCE - Score 1 out of 6
DONOTAGE - Score 1 out of 6
The above companies are suspicious and should be avoided. 
ULTRAHEALTH - Score 6 out of 6
| Price per gram |
$2.79/ gm* |
| Dosage per Capsule | 300 mg |
| Pure synthesized / Extracted | yes / no |
| absorption / effectiveness criteria |
|
| trans resveratrol |
yes |
| Pure - no added Ingredients | yes |
| True Liposomal capsule / bio-available | yes |
| reliability criteria |
|
| Correct FDA Required Label | yes |
| Real UPC number | yes |
|
GMP Certification number |
11625918556 |
| * includes our VC10 discount for 10% off |
GENEX Score 3 out of 6
GENEX
| Price per gram |
$0.88 / gm |
| Dosage per Capsule | 250 mg |
| Pure synthesized / Extracted | no / yes |
| absorption / effectiveness criteria | |
| trans resveratrol |
yes |
| Pure - no added Ingredients | no |
| True Liposomal / bio-available | no |
| reliability criteria | |
| Correct FDA Required Label | yes |
| Real UPC number | yes |
|
GMP Certification number |
no |
DOUBLEWOOD - Score 3 out of 6
DOUBLEWOOD
| Price per gram |
$1.33 / gm |
| Dosage per Capsule | 250 mg |
| Pure synthesized / Extracted | no / yes |
| absorption / effectiveness criteria | |
| trans resveratrol |
yes |
| Pure - no added Ingredients | no |
| True Liposomal / bio-available | no |
| reliability criteria | |
| Correct FDA Required Label | yes |
| Real UPC number | yes |
|
GMP Certification number |
no |
LIFE EXTENSION - Score 3 out of 6
LIFE EXTENSION
| Price per gram |
$1.72 / gm |
| Dosage per Capsule | 222 mg |
| Pure synthesized / Extracted | no / yes |
| absorption / effectiveness criteria | |
| trans resveratrol |
yes |
| Pure - no added Ingredients | no |
| True Liposomal / bio-available | no |
| reliability criteria | |
| Correct FDA Required Label | yes |
| Real UPC number | yes |
|
GMP Certification number |
no |
PROHEALTH - Score 3 out of 6
PROHEALTH
| Price per gram |
$2.07 / gm |
| Dosage per Capsule | 500 mg* |
| Pure synthesized / Extracted | no / yes |
| absorption / effectiveness criteria | |
| trans resveratrol |
yes |
| Pure - no added Ingredients | no |
| True Liposomal / bio-available | no |
| reliability criteria | |
| Correct FDA Required Label | yes |
| Real UPC number | yes |
|
GMP Certification number |
no |
| *error, you cannot fit 500mg in one capsule. Plus they have an added 210mg. |
TONIIQ - Score 3? out of 6
TONIIQ
| Price per gram |
$1.17 / gm |
| Dosage per capsule | 300mg |
| Pure synthesized / Extracted | no / yes |
| absorption / effectiveness criteria | |
| trans resveratrol |
yes |
| Pure - no added Ingredients | no |
| True Liposomal / bio-available | no |
| reliability criteria | |
| Correct FDA Required Label | yes? |
| Real UPC number | yes? |
|
GMP Certification number |
no |
NOOTROPICS - Score 3? out of 6
NOOTROPICS
| Price per gram |
$1.50 / gm |
| Dosage per Capsule | 500 mg* |
| Pure synthesized / Extracted | no / yes |
| absorption / effectiveness criteria | |
| trans resveratrol |
yes |
| Pure - no added Ingredients | no |
| True Liposomal / bio-available | no |
| reliability criteria | |
| Correct FDA Required Label | yes? |
| Real UPC number | yes? |
|
GMP Certification number |
no |
| *error, you cannot fit 500mg in one capsule. |
LUMINA - Score 2 out of 6
LUMINA
| Price per gram |
$4.44 / gm |
| Dosage per Capsule | 300 mg |
| Pure synthesized / Extracted | no / yes |
| absorption / effectiveness criteria | |
| trans resveratrol | yes |
| Pure - no added Ingredients | no |
| True Liposomal / bio-available | no |
| Correct FDA Required Label | no |
| reliability criteria | |
| Real UPC number | no |
|
GMP Certification number |
no |
RENUE BY SCIENCE - Score 1 out of 6
RENUE BY SCIENCE
| Price per gram |
$3.73 / gm |
| Dosage per Capsule | 125 mg |
| Pure synthesized / Extracted | no / yes |
| absorption / effectiveness criteria | |
| trans resveratrol |
yes |
| Pure - no added Ingredients | no |
| True Liposomal / bio-available | no |
| reliability criteria | |
| Correct FDA Required Label | no |
| Real UPC number | no* |
|
GMP Certification number |
no |
| *The Ishai Createive Group Inc. owns UPC |
DONOTAGE - Score 1 out of 6
DONOTAGE
| Price per gram |
$10.13 / gm |
| Dosage per Capsule | 500 mg* |
| Pure synthesized / Extracted | no / yes |
| absorption / effectiveness criteria | |
| trans resveratrol |
yes |
| Pure - no added Ingredients | no |
| True Liposomal / bio-available | no |
| reliability criteria | |
| Correct FDA Required Label | no |
| Real UPC number | no |
|
GMP Certification number |
no |
| *error, you cannot fit 500mg in one capsule. |
Back to Table of Contents
Resveratrol Supplements – Product Reviews
We have not included some companies because they are lesser know, in other overseas countries or to awful to list.
Please us our contact page to ask any questions or request a company to be reviewed.